Chinese Slimming Tea Bishengyuan for weight loss Researches
Effectiveness of green tea on weight loss in obese Thais: A randomized,
controlled trial.
Auvichayapat P, Prapochanung M, Tunkamnerdthai O, Sripanidkulchai BO,
Auvichayapat N, Thinkhamrop B, Kunhasura S, Wongpratoom S, Sinawat S,
Hongprapas P.
Department of Physiology, Faculty of Medicine, Khon Kaen University,
40002, Thailand.
This study was undertaken to investigate the effects of green tea on
weight loss in obese Thais. A randomized, controlled trial involving 60
obese subjects (body mass index, BMI > 25 kg/m2) was conducted. All
subjects consumed a Thai weight loss diet containing 3 meals (8373.6
kJ/day) for 12 weeks, prepared by the Nutritional Unit at Srinagarind
Hospital. The weight loss diet contained 65% carbohydrates, 15% protein,
and 20% fat. Body weight, BMI, body composition, resting energy
expenditure, and substrate oxidation were measured at baseline, and
during weeks 4, 8, and 12 of the study. Serum levels of leptin and urine
VMA were measured at baseline and during the 12th week. Differences over
time and between the weight loss treatments (green tea or placebo) over
time were determined using two-factor ANOVA with repeated measures. In
comparing the two groups, differences in weight loss were 2.70, 5.10,
and 3.3 kg during the 4th, 8th, and 12th weeks of the study,
respectively. At the 8th and 12th weeks of the study, body weight loss
was significantly different (P < 0.05). At the 8th week, the difference
in resting energy expenditure was 183.38 kJ/day (P < 0.001), the
difference in the respiratory quotient was 0.02 (P < 0.05), and no
significant differences existed in satiety score, food intake, or
physical activity. Urine VMA was significantly different in the 12th
week of the study (P < 0.05). We conclude that green tea can be
effective weight loss in obese Thai subjects by increasing energy
expenditure and fat oxidation.
A mixture of extracts of black
and green teas and mulberry leaf did not reduce weight gain in rats fed
a high-fat diet.
Fallon E, Zhong L, Furne JK, Levitt M.
Research Service (151), Minneapolis Veterans Affairs Medical Center.
Tea extracts are used in many over-the-counter preparations claiming to
promote weight loss. The rationale for this usage includes reports that
weight loss green tea extract increases thermogenesis, and extracts of
green and black tea and mulberry leaf inhibit the digestion/absorption
of carbohydrate and fat. The investigators in this study tested the
potential of increasing doses of a weight loss mixture of three extracts
(50-percent black tea, 20-percent green tea, and 30-percent mulberry) to
induce weight loss, steatorrhea, and blood lipid alterations in rats
ingesting a high-fat diet, ad lib. The weight loss mixture was
incorporated into chow in quantities of 0.5-, 3.0-, and 6.0 percent by
weight; a control group received only chow. Food intake and weight loss
were monitored daily, and quantitative fecal fat measurements were
obtained weekly for four weeks. The 3.0- and 6.0-percent chows
significantly increased fecal fat excretion to 15 percent of dietary fat
intake (controls: 5 percent); however, no significant reduction in
weight loss was observed. After four weeks of weight loss treatment, the
3.0- and 6.0-percent dosages were associated with significant reductions
in serum triglycerides and increases in high-density lipoprotein (HDL)
cholesterol. However, these chow concentrations were associated with
significant increases in serum ALT, and the 6.0-percent chow markedly
increased serum alkaline phosphatase. This weight loss study does not
provide support for the utility of this combination of black tea, green
tea, and mulberry extracts in weight-loss regimens and indicates that
high doses of this extract combination may be hepatotoxic.
The
effects of epigallocatechin-3-gallate on thermogenesis and fat oxidation
in obese men: a pilot study.
Boschmann M, Thielecke F.
Universitary Medicine Berlin, Charité Campus Buch, Franz-Volhard-Center
for Clinical Research, D-13125, Berlin, Germany.
OBJECTIVES: The development of obesity is characterized by an increase
in adipose tissue mass and by concomitant and profound changes in almost
all organ functions leading to diseases such as hypertension, diabetes
mellitus and coronary heart disease. Recent data from human studies
indicate that the consumption of green tea and green tea extracts may
help weight loss, mainly body fat, by increasing postprandial
thermogenesis and fat oxidation. However, human studies investigating
the metabolic effects of the most predominant tea catechin, EGCG, alone
are absent. METHODS: In a randomized double blind, placebo-controlled,
cross-over pilot study, six overweight men were given weight loss 300 mg
EGCG/d for 2d. Fasting and postprandial weight loss changes in energy
expenditure (EE) and substrate oxidation were assessed. RESULTS: Resting
EE did not differ significantly between EGCG and placebo treatments,
although during the first postprandial monitoring phase, respiratory
quotient (RQ) values were significantly lower with weight loss EGCG
compared to the placebo. CONCLUSIONS: These findings suggest that weight
loss EGCG alone has the potential to increase fat oxidation in men and
may thereby contribute to the weight loss effects of green tea. However,
more studies with a greater sample size and a broader range of age and
BMI are needed to define the optimum dose for weight loss.
Green tea
extract thermogenesis-induced weight loss by epigallocatechin gallate
inhibition of catechol-O-methyltransferase.
Shixian Q, VanCrey B, Shi J, Kakuda Y, Jiang Y.
South China Institute of Botany, Chinese Academy of Sciences, Guangzhou,
China.
Epidemiological studies have shown that intake of weight loss tea
catechins is associated with a lower risk of cardiovascular disease. The
antioxidative activity of weight loss tea-derived catechins has been
extensively studied. Reports have shown that weight loss green tea
extract intake is associated with increased weight loss due to
diet-induced thermogenesis, which is generally attributed to the
catechin epigallocatechin gallate. That weight loss catechin-polyphenols
are known to be capable of inhibiting catechol-O-methyltransferase (the
enzyme that degrades norepinephrine) is a possible explanation for why
the weight loss green tea extract is effective in stimulating
thermogenesis by epigallocatechin gallate to augment and prolong
sympathetic stimulation of thermogenesis. Knowledge about thermogenesis-induced
weight loss produced by green tea's epigallocatechin gallate and its
ability to inhibit catechol-O-methyltransferase is important for health
benefits and for prolonging the action of norepinephrine in the synaptic
cleft.
Availability of weight-loss supplements: Results of an audit of retail
outlets in a southeastern city.
Sharpe PA, Granner ML, Conway JM, Ainsworth BE, Dobre M.
Prevention Research Center, Arnold School of Public Health, University
of South Carolina, 921 Assembly St, Columbia, SC 29208, USA.
The sale of nonprescription weight-loss products accounts for millions
of dollars spent by Americans trying to lose weight, yet there is little
evidence for effectiveness and there are multiple safety concerns. The
purpose of this study was to determine what weight loss products, and
ingredients within products, were available at retail outlets in a
metropolitan area. A purposive sampling strategy identified 73 retail
outlets. An audit form was used to collect information from product
labels. The audit identified 402 products containing 4,053 separate
weight loss ingredients. The mean number of ingredients per product was
9.9+/-8.96 (range = 1 to 96). A database search was conducted regarding
evidence for effectiveness, safety precautions, and side effects for the
10 ingredients that appeared most often across products. Modest evidence
of weight loss effectiveness exists for green tea (Camellia sinensis),
chromium picolinate, and ma huang (Ephedra major). For the remaining
seven (ginger root [Zingiber officinale], guarana [Paullinia cupana],
hydroxycitric acid [Garcinia cambogia], white willow [Salix alba],
Siberian ginseng [Eleutherococcus senticosus], cayenne [Capsicum annuum],
and bitter orange/zhi shi [Citrus aurantium]), inadequate or negative
weight loss evidence exists. Although precautions and contraindications
were found for all 10 ingredients, the strongest concerns in the
literature appear for ma huang, bitter orange, and guarana. Our audit
revealed numerous weight-loss products available to consumers, yet there
is little evidence to support the effectiveness of the top 10
ingredients identified and many potential adverse reactions; therefore,
food and nutrition professionals should discuss dietary weight loss
supplement use with their clients.
Potential
applications for alternative weight loss medicine to treat obesity in an
aging population.
Cherniak EP.
Division of Geriatrics and Gerontology, Miller School of Medicine,
University of Miami and the Miami VA Health Care System. Correspondence
address: Room 1D200, Miami VA Medical Center, 1201 NW 16 Street, Miami,
FL 33125.
Obesity is a growing problem causing significant morbidity and
mortality. The efficacy of conventional therapies is limited. Numerous
alternative therapies are advocated for weight loss, including dietary
modifications, hypnotherapy, and acupuncture. Many herbal medications
and weight loss dietary supplements such as conjugated linoleic acids,
chitosan, Garcinia cambogia, and Citrus aurantium, are also being used.
Most have been tested in very limited trials. None have been evaluated
to the extent they can be definitively recommended, nor have they been
studied to ascertain the extent of potential hazards. Given the scope of
the problem, and the potential risk to a vulnerable population, further
research should be conducted to define the efficacy of these weight loss
treatments, particularly for the elderly.
Dietary
supplements in weight reduction.
Dwyer JT, Allison DB, Coates PM.
Office of Dietary Supplements, National Institutes of Health, Bethesda,
Maryland 20892, USA.
We summarize evidence on the role of dietary supplements in weight
reduction, with particular attention to their safety and benefits.
Dietary supplements are used for two purposes in weight reduction: (a)
providing nutrients that may be inadequate in weight loss diets and (b)
for their potential benefits in stimulating weight loss. The goal in
planning weight-loss diets is that total intake from food and
supplements should meet recommended dietary allowance/adequate intake
levels without greatly exceeding them for all nutrients, except energy.
If nutrient amounts from food sources in the reducing diet fall short,
dietary supplements containing a single nutrient/element or a
multivitamin-mineral combination may be helpful. On hypocaloric weight
loss diets, the addition of dietary supplements providing nutrients at a
level equal to or below recommended dietary allowance/adequate intake
levels or 100% daily value, as stated in a supplement's facts box on the
label, may help weight loss dieters to achieve nutrient adequacy and
maintain electrolyte balance while avoiding the risk of excessive
nutrient intakes. Many botanical and other types of weight loss dietary
supplements are purported to be useful for stimulating or enhancing
weight loss. Evidence of their efficacy in stimulating weight loss is
inconclusive at present. Although there are few examples of safety
concerns related to weight loss products that are legal and on the
market for this purpose, there is also a paucity of evidence on safety
for this intended use. Ephedra and ephedrine-containing supplements,
with or without caffeine, have been singled out in recent alerts from
the Food and Drug Administration because of safety concerns, and use of
weight loss products containing these substances cannot be recommended.
Dietitians should periodically check the Food and Drug Administration
Web site ( www.cfsan.fda.gov ) for updates and warnings and alert
patients/clients to safety concerns. Dietetics professionals should also
consult authoritative sources for new data on efficacy as it becomes
available ( ods.od.nih.gov ).
Common
dietary supplements for weight loss.
Saper RB, Eisenberg DM, Phillips RS.
Harvard Medical School, Boston, Massachusetts, USA.
Over-the-counter weight loss dietary supplements to treat obesity appeal
to many patients who desire a "magic bullet" for weight loss. Asking
overweight patients about their use of weight-loss supplements and
understanding the evidence for the efficacy, safety, and quality of
these supplements are critical when counseling patients regarding weight
loss. A schema for whether physicians should recommend, caution, or
discourage use of a particular weight-loss supplement is presented in
this article. More than 50 individual dietary supplements and more than
125 commercial combination products are available for weight loss.
Currently, no weight-loss supplements meet criteria for recommended use.
Although evidence of modest weight loss secondary to ephedra-caffeine
ingestion exists, potentially serious adverse effects have led the U.S.
Food and Drug Administration to ban the sale of these weight loss
products. Chromium is a popular weight-loss supplement, but its efficacy
and long-term safety are uncertain. Guar gum and chitosan appear to be
ineffective; therefore, use of these products should be discouraged.
Because of insufficient or conflicting evidence regarding the efficacy
of conjugated linoleic acid, ginseng, glucomannan, green tea,
hydroxycitric acid, L-carnitine, psyllium, pyruvate, and St. John's wort
in weight loss, physicians should caution patients about the use of
these supplements and closely monitor those who choose to use these
products.
Use of
nonprescription dietary supplements for weight loss is common among
Americans.
Blanck HM, Serdula MK, Gillespie C, Galuska DA, Sharpe PA, Conway JM,
Khan LK, Ainsworth BE.
Division of Nutrition and Physical Activity, Centers for Disease Control
and Prevention, Atlanta, GA 30341, USA.
OBJECTIVE: Dietary supplements are not recommended as part of a
weight-loss program due to concerns about efficacy and safety. This
study sought to assess prevalence and duration of nonprescription
weight-loss supplement use, associated weight-control behaviors,
discussion of use with a health care professional, and specific
ingredient use. PARTICIPANTS AND DESIGN: Adults aged > or =18 years
(n=9,403) completed a cross-sectional population-based telephone survey
of health behaviors from September 2002 through December 2002.
STATISTICAL ANALYSES PERFORMED: Both chi2 and t tests were conducted for
categorical and mean comparisons and multiple variable logistic
regression was used to determine significant predictors. RESULTS: An
estimated 15.2% of adults (women 20.6%, men 9.7%) had ever used a
weight-loss supplement and 8.7% had past year use (women 11.3%, men
6.0%); highest use was among women aged 18 to 34 years (16.7%). In
regression models, use was equally prevalent among race/ethnic groups
and education levels. One in 10 (10.2%) of users reported > or =12 month
use, with less frequent long-term use in women (7.7%) than men (15.0%),
P=0.01. Almost one third (30.2%) of users discussed use during the past
year; 73.8% used a supplement containing a weight loss stimulant
including ephedra, caffeine, and/or bitter orange. CONCLUSIONS: Use of
supplements for weight loss seems to be common among many segments of
the US adult population. Many adults are long-term users and most do not
discuss this practice with their physician. Most of the weight-loss
supplements taken contain stimulants. Qualified professionals should
inquire about use of supplements for weight loss to facilitate
discussion about the lack of efficacy data, possible adverse effects, as
well as to dispel misinformation that may interfere with sound
weight-management practices.
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