Objective: Ache is the commom symptom of many diseases in clinic. At present, most of the analgesics used in clinic therapy had addiction and obvious adverse drug reaction, so it is far-reaching significant to develop a high-effect and low-toxicity analgesic. Yuanhu Zhitong Pian composed by CORYDALIS YANHUSUO W. T. WANG and ANGELICA DAHURICA is recorded in Chinese Pharmacopeia since 1985 for its simple anagraph and difinite effect, it has obvious analgesic effect without the common toxicity and adverse drug reaction of chemicals, especially absence of dependence. At present, CORYDALIS YANHUSUO W. T. WANG and ANGELICA DAHURICA were extracted by alcohol refluxing method in pharmaceutical industry, which exists many limitations such as mass extract, consuming lots of solvent etc. Available Yuanhu Zhitong preparations are inadvanced in preparation form and absent in quality control, so it is necessary to improve extraction, preparation form and quality control of available YuanhuZhitong preparation. Methods:The CO_2-SFE of CORYDALIS YANHUSUO W. T. WANG (1)The content of tetrahydropalmatine(THP) was determined by HPLC, which was considered as a quality control of extraction process; (2)To compare the THP extraction rate of different alkalinized methods; (3)On the basis of mono-factor testing, uniform design was used to optimize the extraction technique of CORYDALIS YANHUSUO W. T. WANG , which was evaluated by comparing the content of THP; (4)The comparison was done between CO2-SFE and alcohol refluxing method for the extraction effect of effective components from CORYDALIS YANHUSUO W. T. WANG.

Effects of Corydalis yanhusuo and Angelicae dahuricae on Cold Pressor-Induced Pain in Humans: A Controlled Trial
Chun-Su Yuan, MD, PhD, Sangeeta R. Mehendale, MD, PhD, Chong-Zhi Wang, PhD, Han H. Aung, MD, Tingliang Jiang, MD, PhD, Xiongfei Guan, MD and Yukihiro Shoyama, PhD
From the Tang Center for Herbal Medicine Research, Committee on Clinical Pharmacology, and Department of Anesthesia & Critical Care, Pritzker School of Medicine, University of Chicago, Illinois, and Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Pain is considered the most common complaint worldwide for which patients seek treatment. Conventional analgesic agents play an important role in modern pain therapy, but they cause several adverse effects. Therefore, newer and better analgesics continue to be investigated. In this controlled clinical trial, the authors evaluated the analgesic effects of 2 herbal medicines, Corydalis yanhusuo and Angelicae dahuricae. They used the cold-pressor test—a simple, reliable, and widely used model in humans—for induction of tonic pain. They demonstrated that after a single, oral administration of the extracts of C. yanhusuo and A. dahuricae, the pain intensity and pain bothersomeness scores significantly decreased (both P < .01). Dose-related analgesic effect was also observed. Results from this study suggest that C. yanhusuo and A. dahuricae may have a potential clinical value for treating mild to moderate pain.Effects of Four Herbal Extracts on Adjuvant-Induced Inflammation and Hyperalgesia in Rats
To cite this paper:
F. Wei, S. Zou, A. Young, R. Dubner, K. Ren. The Journal of Alternative and Complementary Medicine. October 1, 1999, 5(5): 429-436. doi:10.1089/acm.1999.5.429.
F. Wei, M.D., Ph.D.
Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore, Maryland.
S. Zou, B.S.
Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore, Maryland.
A. Young
Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore, Maryland.
R. Dubner, D.D.S., Ph.D.
Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore, Maryland.
K. Ren, M.D., Ph.D.
Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore, Maryland.
Objective: To evaluate the effects of four herbal medicine extracts on a rat model of inflammatory hyperalgesia.
Design/Interventions: Inflammation was induced by injecting complete Freund's adjuvant (CFA) into one hindpaw of each rat. Four herbs that are routinely prescribed in Traditional Chinese Medicine for treatment of pain were used: Duhuo (Radix Angelicae Pubescentis), Bai Jiang cao (Patriniae Herba cum Radice), Yan hu suo (Rhizoma Corydalis) and Sanqui (Panax Notoginseng). The crude water extracts of the herbs were inected intraperitoneally following a repeated treatment profile.

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