Chuan Bei Pi Pa Gao
Medicine Researches
The Chinese herbal medicine formula MSSM-002 suppresses
allergic airway hyperreactivity and modulates TH1/TH2 responses in a murine
model of allergic asthma
Xiu-Min Li MDaa, Chih-Kang Huang MSaa, Teng-Fei Zhang PhDaa, Ariel A. Teper MDaa,
Kamal Srivastava BSaa, Brian H. Schofield JDba and Hugh A. Sampson MDaa
Background: Asthma is a major public health problem worldwide, and the morbidity
and mortality of asthma have increased in the past two decades. The reputed
efficacy, low cost, and relative absence of side effects of traditional Chinese
medicines (TCMs) have led to increasing interest in the use of TCMs for the
treatment of asthma in Western countries. However, there are few well-controlled
scientific studies on the efficacy, safety, and mechanisms of action of TCMs
used to treat asthma. Objective: The goal of this study was to investigate the
effects of the Chinese herbal medicine formula MSSM-002, derived from TCMs used
to treat allergic asthma, on a well-characterized mouse model of allergic
asthma. Methods: Mice sensitized intraperitoneally and challenged
intratracheally with conalbumin were treated with MSSM-002 24 hours after the
first intratracheal challenge. Dexamethasone-treated, saline solution
sham-treated, and naive mice served as controls. The effects of MSSM-002 on
allergic airway hyperreactivity, inflammation, antigen-specific antibody
production, lung histologic features, and cytokine profiles were evaluated.
Results: MSSM-002 treatment virtually eliminated airway hyperreactivity and
markedly reduced the total number of cells and the percent eosinophils in
bronchoalveolar lavage fluids compared with the sham-treated group. Lung
histologic features showed that MSSM-002 reduced inflammation and mucus
production. These effects were equivalent to the effects of dexamethasone, but
in contrast to the overall immunosuppressive effects of dexamethasone MSSM-002
treatment decreased antigen-specific IgE, IL-4, IL-5, and IL-13 levels without
suppressing IgG2a and IFN-γ synthesis. Conclusion: MSSM-002 exhibits anti–airway
hyperresponsiveness, anti–airway inflammation, and immunoregulatory effects on
TH1/TH2 responses, which may be useful for treatment of allergic asthma. (J
Allergy Clin Immunol 2000;106:660-8.)
Comparison of the Content of Peimine in Chuanbeipipa Syrup Produced
by Different FactoriesTLCS for
the determination of imperialine in Chuanbei Pipa syrup
Treatment of Radiation Esophagitis by
Niancian' s Chuanbei Pipa Gao Combined with Yunnan Baiyao: A
Clinical Observation of 32 Cases
Revised Standard of Milian Chuanbei Pipa
Concentrated Decoction in Pharmacopoeia of the People's Republic of
China 2005 Edition ( I )
Determination of Hesperidin in the Chinese
Patent Medicine of Milian Chuanbei Pipa Gao by HPLC Combined with
Solid -phase Extraction
Study on Quality Standard for Chuanbei Pipa
Syrups
2005 Huang Jingfang , Lin Meiqing
Tlc scanning for the determination of
imperialine in Chuanbei Pipa Buccal Tablets
Chinese medicinal herbs for acute bronchitis.
Wu T, Chen X, Duan X, Juan N, Liu G, Qiao J, Wang Q, Wei J, Zhen J, Zhou L.
Chinese Cochrane Centre, Chinese Evidence-Based Medicine Centre & Regional
Clinical Epidemiology Resource & Training Centre, West China Hospital, Sichuan
University, No. 37, Guo Xue Xiang, Chengdu, Sichuan, China, 610041.
BACKGROUND: Acute bronchitis is one of the most common diagnoses made by
primary-care physicians. It is traditionally treated with antibiotics, (although
the evidence for their effectiveness is weak and modest at best), and other even
less effective treatments. Chinese medicinal herbs have been also used as
treatment. OBJECTIVES: This review aims to summarise the existing evidence on
the comparative effectiveness and safety of Chinese medicinal herbs for treating
uncomplicated acute bronchitis. SEARCH STRATEGY: We searched the Cochrane
Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 1,
2005), which includes the Cochrane Acute Respiratory Infections Group's
specialised register; The Chinese Cochrane Centre's Controlled Trials Register
(up to December 2004); MEDLINE (1966 to March Week 1, 2005); EMBASE (1988 to
December 2004); and the Chinese Biomedical Database (CBM) (1980 to December
2004). SELECTION CRITERIA: Randomised controlled trials comparing Chinese
medicinal herbs with placebo, antibiotics or other Western medicines for the
treatment of uncomplicated acute bronchitis. DATA COLLECTION AND ANALYSIS: At
least two authors extracted data and assessed trial quality. MAIN RESULTS: Four
trials reported the time to improvement of cough, fever, and rales associated
with bronchitis and showed that patients treated with Chinese herbs had a
shorter duration of signs and symptoms. Two trials reported the proportion of
patients with improved signs and symptoms at follow up and showed that Chinese
herbs were beneficial in terms of relief of signs and symptoms. Thirteen trials
analysed the data on physician global assessment of improvement at follow up.
Nine of thirteen trials showed that Chinese herbs were superior to routine
treatment and the other four trials showed a similar effect to routine
treatment. In general, Chinese herbs appeared beneficial. Only one trial
reported on adverse effects during treatment. AUTHORS' CONCLUSIONS: There is
insufficient quality data to recommend the routine use of Chinese herbs for
acute bronchitis. The benefit found in this systematic review could be due to
publication bias and study-design limitations of the individual studies. In
addition, the safety of Chinese herbs is unknown due to the lack of
toxicological evidence on these Chinese herbs, though adverse events are rarely
reported. Chinese herbs should be used carefully.
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