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Pharmacokinetics of chuan xin lian tablet in healthy Chinese volunteers
Hong X, Huang TL, Mi SQ, Ye SM, Ou WP, Wang NS.
Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China
OBJECTIVE: To study pharmacokinetics of debydroandrographolide, that is a main active component in chuan xin lian tablet, in healthy Chinese volunteers. METHODS: Eight volunteers were chosen for a single dose of two chuan xin lian tablet drug concentrations in plasma were measured by HPLC-MS method and the pharmacokinetic parameters were calculated by PK Solution 2.0 software. RESULTS: t(1/2) ka, t(1/2) alpha, t/(1/2) beta, Cmax, tmax and AUCO-t were (0.51 +/- 0.28) h, (0.60 +/- 0.33) h, (3.62 +/- 1.16) h, (147.30 +/- 53.29) microg x L(-1), (1.50 +/- 0.21) h, and (256.63 +/- 64.18) microg x h x L(-1), respectively. CONCLUSION: Dehydroandrographolide has rapid absorption and long elimination rate after oral administration. The results can provide an evidence for the safety and efficiency of chuanxinlian tablet in clinical application.
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