Xiao Yao Wan
Medicine Researches
Treatment of breast proliferation disease with modified xiao yao san
and er chen decoction
Zhang GL.
Dept. of Surgery TCM, First Affiliated Hospital, Shanxi Medical
College, Taiyuan.
The authors report the 3 months' treatment of 51 cases of breast
proliferation disease with modified Xiao Yao San and Er Chen
decoction, an effective rate being 96.1%. In each patient before and
after treatment, saliva estradiol (SE2), saliva progesterone (SP),
saliva testosterone (ST) and plasma prolactin (PRL) concentrations
were monitored and breast molybdenum-target X-ray films were taken.
The results showed that after treatment, SE2 concentrations declined
very significantly (P less than 0.001); SP concentrations declined
significantly (P less than 0.05); PRL concentrations declined very
significantly (P less than 0.005), but ST concentrations did not
change significantly. Breast molybdenum-target X-ray films showed
absorption of proliferation masses in 21 cases. These indicated that
the medicine could regulate endocrine system, perhaps through
suppressing secretion of PRL, decreasing prolactin antagonist action
to follicular stimulating hormone so as to restore follicle
function, and could regulate pituitary-follicle axis and make the
axis normal.The identification
and determination of marker substances in xiaoyao wan by three
dimensional HPLC
Chen FK, Meng XS, Guo YZ, Kano Y.
Shenyang College of Pharmacy.
A Chinese traditional patent medicine Xiaoyao Wan was analysed by
three dimensional HPLC. The result shows that the Chinese
traditional medicines involved in Xiaoyao Wan were identified
excellently and the content of marker substances can be determined
accurately. According to the results of determination, the content
of saikosaponin b1, b2, glycyrrhizin, paeoniflorin and
atractylenolide III in Xiaoyao Wan was 0.43, 0.53, 5.22, 3.95 and
0.16 (mg/g), respectively; The RSD was 1.2, 0.8, 0.4, 0.3 and 1.0
(%) respectively.
450 cases of replenishing qi and xiao yao
wan in the treatment of female chloasma
Journal of Jinggangshan Medical College 2001
Effects of chai hu (radix burpleuri) containing formulation on
plasma beta-endorphin, epinephrine and dopamine on patients.
Chen JX, Ji B, Lu ZL, Hu LS.
Department of TCM Diagnostics, School of Pre-clinical Medicine
Beijing University of Traditional Chinese Medicine, Beijing 100029,
China
Chai Hu (Radix Burpleuri), a major ingredient in many traditional
Chinese medicine formulas, such as Xiao Yan Wan, is used in the
treatment of liver stagnation and spleen deficiency syndrome (LSSDS).
The objectives of this study were to examine the effects of Xiao Yao
Wan containing Chai Hu on the changes of plasma indices in patients
with LSSDS. Fifty-eight cases of LSSDS were randomly divided into
two groups: 41 cases in the experimental group were treated with
Xiao Yao Wan containing Chai Hu and 17 cases in the control group
were treated with Zhi Bai Di Huang Wan for one consecutive month in
a single blind design. Before and after treatment, high performance
liquid chromatography (HPLC) was applied to determine the changes of
plasma norepinephrine (NE), epinephrine (E) and dopamine (DA).
Radioimmunoassay was performed to measure the amount of plasma
beta-endorphin (beta-EP), adrenocorticotropin hormone (ACTH),
estradiol (E2) and testosterone (T), and laser nephelometry was also
conducted to measure plasma immunoglobulin A (Ig A) and G (Ig G).
Compared to baseline levels, plasma beta-EP was significantly
increased (p < 0.01), while E and DA were markedly decreased (p <
0.01) after the administration of Xiao Yao Wan in the experimental
group. The other indices did not change. This is the first evidence
showing that the effect of Xiao Yao Wan containing Chai Hu on the
treatment of patients with LSSDS may be through enhancing plasma
beta-EP and decreasing E and DA release. We conclude that Xiao Yao
Wan containing Chai Hu regulates nervous and endocrine systems and
contributes to the improvement of the clinical status of patients
with LSSDS.
Simultaneous analysis of glycyrrhizin, paeoniflorin, quercetin,
ferulic acid, liquiritin, formononetin, benzoic acid and
isoliquiritigenin in the Chinese proprietary medicine Xiao Yao Wan
by HPLC.
Xie J, Wang W, Zhang Y, Bai Y, Yang Q.
School of Chinese Materia Medica, Beijing University of Chinese
Medicine, Beijing 100029, China.
A high performance liquid chromatography coupled with
photodiode-array detection method was developed for simultaneous
determination of glycyrrhizin, paeoniflorin, benzoic acid, quercetin,
ferulic acid, formononetin, liquiritin and isoliquiritigenin in the
Chinese proprietary medicine "Xiao Yao Wan" (XYW). The analysis was
performed by reverse phase gradient elution, using an aqueous mobile
phase (containing 0.1% phosphoric acid) modified by acetonitrile and
detection made simultaneously at four wavelengths. The method was
validated for accuracy, precision and limits of detection and
quantification. Ten batches of Xiao Yao Wan obtained from different
pharmaceutical companies were analyzed and found to contain
different amounts of the eight bioactive markers. This method could
be used for quality assessment of this herbal medicine.
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