Zhi Bai Di Huang Wan
Medicine Researches
Experimental Study of Zhi Bai Di
Huang Wan
in Treating Ureaplasma Urealyticum and Enhancing Spermatozoa Motility
Journal of Liaoning College of Traditional Chinese Medicine 2007
Effects of successive cropping Rehmannia
glutinosa on rhizosphere soil microbial flora and enzyme activities
Chen H, Hao HR, Xiong J, Qi XH, Zhang CY, Lin WX.
Institute of Agroecology, Fujian Agriculture and Forestry
University, Fuzhou 350002, China.
With the soils cropped Rehmannia glutinosa for one and two years as
test materials, this paper studied the variations of microbial flora
and enzyme activities in rhizosphere. The results showed that with
increasing year of cropping, the numbers of bacteria and fungi in
rihzosphere had a slight decrease. In the soil successively cropped
R. glutinosa for two years, the number of actinomycetes in
rihzosphere was 4 times higher, the ammonifier, aerobic azotobacter,
sulphate reducer, denitrifier, and anaerobic cellulose-decomposer
increased by 25.99, 45.39, 11.43, 1.36, and 1.43 folds,
respectively, while aerobic cellulose-decomposer reduced by 86.74%,
compared with those in the soil cropped R. glutinosa for one year.
The root exudates of successively cropped R. glutinosa increased the
activities of urease, polyhphenol oxidase, sucrase, protease and
cellulase in rhizosphere by 62.87%, 9.43%, 47.91%, 139.62% and
31.33%, respectively, but inhibited the activity of catalase. The
findings suggested that successive cropping R. glutinosa would
destroy the balance of rhizosphere soil microbial flora.
Further pharmacological evidence of the
neuroprotective effect of catalpol from Rehmannia glutinosa.
Zhang X, Zhang A, Jiang B, Bao Y, Wang J, An L.
School of Environmental and Biological Science & Technology, Dalian
University of Technology, Dalian 116024, China.
We have previously evaluated the neuroprotective effect of catalpol
on aging mice induced by d-galactose, in which catalpol treatment
ameliorated cognition deficits and attenuated oxidative damage in
mice brain. To thoroughly elucidate the anti-aging effects of
catalpol, the liver and spleen antioxidative systems and energy
metabolism in senescent mice induced by d-galactose have been
studied. Except control group, mice were subcutaneously injected
with d-galactose (150mgkg(-1)body weight) for 6 weeks. Meanwhile,
drug group mice were treated with catalpol (2.5, 5, 10mgkg(-1)body
weight) and piracetam (300mgkg(-1)body weight) for the last 2 weeks.
The activities of endogenous antioxidants and the level of
glutathione (GSH) and lipid peroxide in the liver and spleen were
assayed. Compared to control group, model group mice had
significantly lower spleen index (spleen weight/body weight), lower
level of GSH, lower activities of superoxide dismutase (SOD) and
glutathione peroxidase (GSH-PX), higher level of malondialdehyde (MDA)
in the liver and spleen. However, catalpol administration markedly
reversed these effects of senescence induced by d-galactose.
Simultaneously, catalpol noticeably elevated the decreased
activities of lactate dehydrogenase (LDH), glutamine synthetase
(GS), Na(+)-K(+)-ATPase, Ca(2+)-Mg(2+)-ATPase and decreased the
elevated activity of creatine kinase (CK) in mice liver or spleen.
These results implied that the anti-aging effects of catalpol were
achieved at least partly by promoting endogenous antioxidant enzyme
activities and normalizing energy disturbance. Catalpol may be a
potential anti-aging agent and worth testing for further preclinical
study aimed for senescence or neurodegenerative diseases such as
Alzheimer's and Parkinson's diseases.
Experimental Study of Zhi-Bai-Di-Huang Decoction
in Treating Ureaplasma Urealyticum and Enhancing Spermatozoa
Motility The Effects of Extract
of Zhi Bo Di Huang Wan on the [Ca2+]i of Rat Chromaffin Cell
Zhou Zhuan , Zhang Chunguang , Chen Liangyi , Ye Qin
By using microflurescent calcium measurement technique, the effects
of extract of Zhi Bo Di Huang Wan on the intracellular calcium
concentration ([Ca2+]i) of single rat Chromaffin cell were studied.
The results showed the extract caused an increase of [Ca2+]i when it
was puffing to the cell. Removing Ca2+ from the bath solution or
nifedipine obviously inhibited the increasement of [Ca2+]i induced
by the extract. It illustrated that the dependence of the Zhi Bo Di
Huang-triggered calcium signal on extracellular Ca2+ and the opening
of L-Ca2+ Channel made a great contribution to the [Ca2+]i increase.
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