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Protective action of Shuganwan on acute liver injury and its effect on bile secretion in rats Journal of Xi'an Jiaotong University(Medical Sciences)
The action of Shuganwan on experimental gastric ulcer Journal of Xi'an Jiaotong University(Medical Sciences)
Experimental study on gastrointestinal function and analgesic effect of Shuganwan, Chinese Journal of Hospital Pharmacy
Experimental Research of Huangqin Elixation's Protective Effect on Liver Injury Induced by Perchlormethane in Rats Journal of Xianning College(Medical Sciences) ZHENG Hong-hua
Effects of Ursolic Acid on Liver-protection and Bile Secretion, Journal of Chinese Medicinal Materials
Protective Effect of Zhi-Tang-Shu On Liver Injured by CCl4 in Rats Journal of Xianning College(Medical Sciences) Li Yun
Protective effect of Fenugreek Seed on Acute Chemical Liver Injury [Chinese Journal of Industrial Medicine]
Experimental study on treatment of epigastralgia with Shu gan wan Pills [ Chinese Traditional Patent Medicine]
Studies on liver-protection and promoting bile secretion of gentiopicroside [ Chinese Traditional and Herbal Drugs]
Experimental study of Anisodamine against hepatic ischemia-reperfusion injury [Chinese Journal of Critical Care Medicine] SHI Liu-bin
The liver-protective and immunomodulative effect of Shahepatide in mice with immune liver injury [Chinese Journal of New Drugs] WU Wu-tong
Protective Effects of Oral Fructose-1, 6-diphosphate on Liver Injury in Animal Models [ Journal of Chinese Pharmaceutical Sciences]
Aim To investigate the effects of FDP on different liver injury models to explore the possibility of FDP used as an oral liver protective agent. Methods Chronic liver injury model in rats was induced by carbon tetrachloride (CCl4); Acute liver injury model in mice was induced by aminogalactose (GaIN) or lipopolysaccharide (LPS). Results In CCl4-induced chronic liver injury model, FDP (1 - 4 g·kg-1·d-1, q.d., for 10 weeks) significantly lowered ALT, AST, γ-glutamyl transpeptidase (γ-GT), alkaline phosphatase (ALP), and total bilirubin (T-BIL) in serum compared with vehicle; simultaneously it evidently elevated abnormal total protein (TP), albumin (ALB) and total cholesterol ( T-CHO ) levels in serum; it also dose-dependently reduced hydroxyproline contents in hepatic tissue. 4 g·kg-1·d-1 of FDP apparently decreased incidence of hepatic cirrhosis, and alleviated pathological changes of liver tissue. In GaIN-induced model, 1.0-4.0 g·kg-1·d-1 of FDP ( bid, for 3 d ) significantly lowered alanine aminotransferase ( ALT ) and aspartate aminotransferase ( AST ) levels in serum; it also decreased liver coefficient. 4.0 g·kg¡ß1·d¡ß1 of FDP significantly alleviated pathological changes of cell ultra-structures. In LPS-induced model, only high dose of FDP (4.0 g·kg¡ß1·d¡ß1, bid, for 12 d) significantly decreased ALT level in serum. Conclusion This study first demonstrated the protective effect of oral FDP on chronic liver injury caused by CCl4, and confirmed its effect on acute liver injury at the same time, suggesting that Long-term oral FDP is efficacious against liver injury induced by different factors and can be used as an oral liver protective agent in clinic.
The protective effect of anti-TNF-α McAb on acute liver injury in rats with endotoxemia [Journal of Jilin Medical College]
Antioxide function of dexamethasone and it's protective effect on the acute liver injury induced by D- GalN/LPS [ Chinese Journal of Critical Care Medicine] XING Hui-chun , ZHANG Jian-xin , TIAN Cai-qin
SYNTHESIS, PRELIMINARY ANTIGASTRELCOSIS ACTIVITY AND THE PROTECTIVE EFFECT ON ACUTE LIVER INJURY OF ZINC CHLORIN E4 [ Acta Pharmaceutica Sinica] LU Jia-guo
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