Shi Quan Da Bu Wan
Medicine Researches
Complementary/Alternative therapies for the treatment of breast
cancer. A systematic review of randomized clinical trials and a
critique of current terminology.
Ernst E, Schmidt K, Baum M.
Complementary Medicine, Peninsula Medical School, Exeter, UK.
The objectives of this study was to evaluate and critically analyze
all randomized clinical trials (RCTs) of ''alternative cancer
cures'' (ACCs) for breast cancer. The electronic databases Cochrane
Central Register of Controlled Trials, MEDLINE, EMBASE, Allied and
Complementary Medicine, Scirus, BIOSIS, CancerLit and CINAHL and for
ongoing trials the MetaRegister at http://www.controlled-trials.com/
and the National Research Register at http://www.update-software.com/national/
were searched from their inception. Bibliographies of located
studies were scanned. Unpublished or ongoing trials were identified
through correspondence with experts in the field. Our own files were
hand searched for further RCTs. Review methods included a systematic
review of RCTs involving breast cancer patients treated with ACCs,
survival, parameters indicative of tumor burden, disease
progression, cancer recurrence, and cancer cure. Results were
tabulated and summarized. Thirteen RCTs met the inclusion criteria.
In most cases their methodological quality is low, with only two
RCTs scoring ''4'' and four RCTs scoring ''3'' out of 5 possible
points for methodological quality. The treatments tested included
various methods of psychosocial support such as group support
therapy, cognitive behavioral therapy cognitive existential group
therapy, a combination of muscle relaxation training and guided
imagery, the Chinese herbal remedy
Shi Quan Da Bu Wan
thymus extract, transfer factor, melatonin, and factor AF2.
Encouraging but not fully convincing results emerged for melatonin.
Surface expression of toll-like receptor 4 on
THP-1 cells is modulated by Bu-Zhong-Yi-Qi-Tang and Shi-Quan-Da-Bu-Tang.
Mita Y, Dobashi K, Shimizu Y, Nakazawa T, Mori M.
First Department of Internal Medicine, Gunma University Faculty of
Medicine, Gunma, Japan.
Human Toll-like receptor 4 (TLR4) has recently been identified and
has been shown to be the main protein involved in recognizing
Gram-negative bacteria. We examined the regulation of TLR4 surface
expression in a human monocytic cell line (THP-1 cells) by two
traditional Chinese herbal medicines. Bu-Zhong-Yi-Qi-Tang (TJ-41)
and Shi Quan Da Bu Wan (TJ-48). TJ-41 and
TJ-48 upregulated TLR4 surface expression in THP-1 cells, as well as
enhanced TLR4 surface expression in these cells both dose- and
time-dependently. These findings suggest that TJ-41 and TJ-48
increase the receptor involved in the response to Gram-negative
bacteria and may enhance defenses against these pathogens.
Effects of Erkang, a modified formulation
of Chinese folk medicine Shi Quan Da Bu Wan,
on mice.
Wu Y, Zhang Y, Wu JA, Lowell T, Gu M, Yuan CS.
Institute of Cancer Medicine, Harbin Medical University, People's
Republic of China.
Shi Quan Da Bu Wan is a traditional
Chinese herbal medicine formula used to increase vital energy, and
strengthen health and immunity. Data from previous studies
demonstrated that this formula also has the ability to attack tumor
tissue. The Erkang capsule is a modified formula of
Shi Quan Da Bu Wan, with the addition of
four other herbs to increase the adaptogen effects and ergogenic
properties. Results from this study in mice indicated that the
Erkang treated group had significant differences in mortality, body
weight change, fatigue, cold temperature endurance, and immune
function related organ weight change, compared to the control
animals.
Inhibition by Shi Quan
Da Bu Wan(TJ-48) of experimental hepatocarcinogenesis induced
by N-nitrosomorpholine in Sprague-Dawley rats.
Tatsuta M, Iishi H, Baba M, Nakaizumi A, Uehara H.
Department of Gastrointestinal Oncology, Center for Adult Diseases,
Osaka, Japan.
The effect of Shi Quan Da Bu Wan (TJ-48)
on hepatocarcinogenesis induced by N-nitrosomorpholine (NNM) was
investigated in male Sprague-Dawley rats. Rats were given drinking
water containing NNM for 8 weeks, and also from the start of the
experiment, regular chow pellets containing 2.0 or 4.0% TJ-48 until
the end of the experiment. Preneoplastic and neoplastic lesions
staining for the placental type of glutathione-S-transferase (GST-P)
or gamma-glutamyl transpeptidase (GGT) were examined histochemically.
In week 15, quantitative histological analysis showed that prolonged
administration of either 2.0 or 4.0% TJ-48 in the diet significantly
reduced the size, volume and/or number of GST-P-positive and GGT-positive
hepatic lesions. This treatment also caused a significant increase
in the proportion of interleukin-2 receptor-positive lymphocytes
among the lymphocytes infiltrating the tumours as well as a
significant decrease in the labelling index of preneoplastic
lesions. These findings indicate that TJ-48 inhibits the growth of
hepatic enzyme-altered lesions, and suggests that its effect may be
in part due to activation of the immune system
Shi Quan Da Bu Wan
(ten significant tonic decoction), SQT. A potent Chinese biological
response modifier in cancer immunotherapy, potentiation and
detoxification of anticancer drugs.
Zee-Cheng RK.
Department of Pharmacology, Toxicology, and Therapeutics, University
of Kansas Medical Center, Kansas City.
Shi Quan Da Bu Wan(Ten Significant Tonic
Decoction), or SQT (Juzentaihoto, TJ-48) was formulated by Taiping
Hui-Min Ju (Public Welfare Pharmacy Bureau) in Chinese Song Dynasty
in AD 1200. It is prepared by extracting a mixture of ten medical
herbs (Rehmannia glutinosa, Paeonia lactiflora, Liqusticum wallichii,
Angelica sinesis, Glycyrrhiza uralensis, Poria cocos, Atractylodes
macrocephala, Panax ginseng. Astragalus membranaceus and Cinnamomum
cassia) that tone the blood and vital energy, and strengthen health
and immunity. This potent and popular prescription has traditionally
been used against anemia, anorexia, extreme exhaustion, fatigue,
kidney and spleen insufficiency and general weakness, particularly
after illness. In order to restore immunity in cancer patients,
potentiate the therapeutic effect and ameliorate adverse toxicity of
anticancer agents, 116 Chinese herbal formularies (Kampo) have been
screened and evaluated. Fifteen compounds were found to have such
actions. Among these, SQT was selected as the most effective as a
potent biological response modifier. During the last eight years,
animal models and clinical studies have revealed that
Shi Quan Da Bu Wan demonstrates extremely
low toxicity (LD50 > 15 g/kg op murine), self-regulatory and
synergistic actions of its components in immunomodulatory and
immunopotentiating effects (by stimulating hemopoietic factors and
interleukins production in association with NK cells, etc.),
potentiates therapeutic activity in chemotherapy (mitomycin,
cisplatin, cyclophosphamide and fluorouracil) and radiotherapy,
inhibits the recurrence of malignancies, prolongs survival, as well
as ameliorate and/or prevents adverse toxicities (GI disturbances
such as anorexia, nausea, vomiting, hematotoxicity,
immunosuppression, leukopenia, thrombocytopenia, anemia and
nephropathy, etc.) of many anticancer drugs. The application and
mechanistic studies of SQT in future development have potential
importance in basic and clinical research of the traditional Chinese
therapeutic approach of "toning the blood and strengthening Qi
(vital energy)" in cancer immunotherapy.
Combination Effects of Herbs in a
Multi-herbal Formula: Expression of Shi Quan Da
Bu Wan Immuno-modulatory Activity on the Intestinal Immune
System.
Kiyohara H, Matsumoto T, Yamada H.
Kitasato Institute for Life Sciences, Kitasato University, Tokyo,
Japan.
Herbal formulas of traditional Japanese (Kampo), Chinese and Korean
medicines usually comprise multiple herbs in a single formula. These
medicines are expected to show their clinical effects by chemical,
pharmacological and pharmaceutical combination effects of
multi-herbs. However, little effort has been made so far to
scientifically clarify the nature of such combination effects.
Interestingly, for example, though a Kampo medicine Juzen-taiho-to (Shi
Quan Da Bu Wan in Chinese) stimulates the immune functions of
Peyer's patch cells, none of its single component herbs shows such
activity. We thus examined the combination effect of herbs in the
Juzen-taiho-to formula for the expression of its immuno-stimulating
activity. Shi Quan Da Bu Wan, a composite
formula of 10 herbs, has been generally considered to comprise two
kinds of basic formula, each of which consists of four different
herbs in addition to two others. The combinations of herbs based on
these two basic formulas were evaluated for their stimulating
activities on cytokine production from murine Peyer's patch cells
both in vitro and ex vivo. Combined decoction of six among 10 herbs
in Juzen-taiho-to is crucial for the expression of its stimulating
activity on Peyer's patch cells. 3D-HPLC analysis of the ingredients
in the fractions from the combined decoctions indicated that, in
addition to quantitative changes of ingredients, alterations occur
in their chemical composition by decoction of different herbs. The
stimulating activity of Shi Quan Da Bu Wan
on Peyer's patch cells results from the combination effect of its
six essential component herbs. This combination effect is based on
physicochemical interactions among the ingredients of the component
herbs.
Effects of Japanese herbal medicine,
Shi Quan Da Bu Wan, in otitis-prone
children - a preliminary study.
Maruyama Y, Hoshida S, Furukawa M, Ito M.
Kurobe City Hospital, Kurobe, Japan.
Conclusion: Shi Quan Da Bu Wan (JTT,
TJ-48), a Japanese herbal medicine that improves immune function,
was found to be effective in otitis-prone in children. Objective: To
evaluate the efficacy of JTT against intractable and recurrent
infections in immature immune systems, we administered JTT to otitis-prone
infants and investigated clinical changes before and during JTT
administration. Subjects and methods: Twenty-four otitis-prone
infants were administered JTT at 0.10-0.14 g/kg/day twice a day for
3 months. We compared clinical course, such as frequency of acute
otitis media (AOM), duration of fever and antibiotics
administration, and hospital visits for the periods before and
during JTT administration. Results: Medication compliance rate was
87.5%, and administration of JTT led to remission in 95.2% patients.
No apparent side effects were observed. The frequency of AOM
decreased significantly (Wilcoxon signed rank test, p=0.000) with
JTT. The duration of fever (p=0.000) and administration of
antibiotics (p=0.001), as well as the number of hospital visits
(p=0.001) and emergent hospital visits (p=0.000) showed significant
decreases after JTT administration. After the end of the JTT period,
14 of 21 (66.7%) patients started to take it again, as they
experienced purulent otitis media and/or other infections after
discontinuation. The frequency of AOM increased significantly after
stopping JTT (p=0.004) and decreased again with JTT resumption
(p=0.005).
This is the page of Chinese medicine for
cancer problems, you can buy
Shi Quan Da Bu Wan online
here. |
