Liu Wei Di Huang Wan Chinese Medicine                                                                                                                                              

ShenYi Center of Chinese Medicine
神医草药中心
Original Chinese Medicines directly from China  

Natural Patent Chinese Formulas

Chinese name: Liu Wei Di Huang Wan (loo way dee hwahng wahn)
                             Six Flavor Tea; Six Ingredient Rehmannia Pills

Ingredients
Rehmannia glutinosa root-prep, Dioscorea opposita rhizome, Cornus officinalis fruit,
Paeonia suffruticosa root-bark, Poria cocos fungus, Alisma plantago aquatica rhizome

Indications
Thirst, irritability, night sweats, insomnia, weak low back and knees

Functions
Tonifies kidney yin, clears heat from yin deficiency conditions

Dosage
6g or 30 pills, two times per day, bottle contains 54g or 270 pills

Manufacturer
Guangdong Lightning Chinese Medicine Co.

Description
Liu Wei Di Huang Wan treats a wide variety of conditions, from insomnia to weakness in the knees. Liu Wei Di Huang Wan is a Chinese Medicinal Formula that is utilized when a patient has been diagnosed as having insufficient liver and kidney yin. It has been considered helpful and is commonly prescribed in China for diminished liver and kidney Yin due to aging, stress, or environment.

This is the classical base formula for all conditions of yin deficiency, especially of the liver and kidneys. Some of the disorders Liu Wei Di Huang Wan treats are diabetes, tuberculosis, hyperthyroidism, nephritis, hypertension, chronic urinary tract infection, and various degenerative diseases of the eyes. With some conditions, such as tuberculosis, Western pharmaceuticals are taken along with the herbs.

Liu Wei Di Huang Wan is a Chinese Medicine whose formula was 1st listed in the "Craft of Medical Treatment for Childhood Disease Patterns" (Xiao Er Yao Zheng Zhi Jue) by Dr. Qian Yi in 1119 AD.
　

Effects of liuwei dihuang pills on expressions of apoptosis-related genes bcl-2 and Bax in pancreas of OLETF rats.
Xue YM, Luo R, Zhu B, Zhang Y, Pan YH, Li CZ.
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province 510515, China.
OBJECTIVE: To investigate the effects of Liuwei Dihuang Pills on expressions of apoptosis-related genes bcl-2 and Bax in pancreas of OLETF rats. METHODS: Forty male OLETF rats were randomly divided into Liuwei Dihuang Pills-treated group and untreated group. Another ten male LETO rats were included in normal control group. OLETF rats in the Liuwei Dihuang Pills-treated group were given Liuwei Dihuang Pills (2.4 g.kg(-1).d(-1)) orally since the age of 8 weeks and the rats in the other two groups were given distilled water orally. Body weights of rats were recorded weekly and blood glucose concentration was determined by oral glucose tolerance test (OGTT). Pancreas weights were recorded after rats were killed and the expression levels of bcl-2 mRNA and Bax mRNA were detected by reverse transcriptase-polymerase chain reaction (RT-PCR). RESULTS: In the Liuwei Dihuang Pills-treated group, the expression of bcl-2 mRNA in the pancreas of rats at the age of 40 weeks (1.25+/-0.07) was much higher than that in the untreated group (1.01+/-0.16), P<0.01. Bax mRNA level in the Liuwei Dihuang Pills-treated group (0.57+/-0.11) was obviously lower than that in the untreated group (1.18+/-0.28), P<0.01. There was no significant difference of pancreas-to-body weight ratios between the Liuwei Dihuang Pills-treated group and the untreated group. The ability of glucose tolerance was improved in the Liuwei Dihuang Pills-treated group. CONCLUSION: Liuwei Dihuang Pills can up-regulate the expression of bcl-2 and down-regulate the expression of Bax at transcription level, which maybe contribute to the anti-apoptosis effects of Liuwei Dihuang Pills.

Clinical study on intervention of liuwei dihuang pill on hormonotherapy in treating nephrotic syndrome. Hu SJ, Fang Q, Liu JS, Zhang L, Cao EZ.
Department of Nephropathy, The First Affiliated Hospital, Anhui TCM University, Hefei 230031
OBJECTIVE: To observe the intervention of liuwei dihuang pill (LDP) on therapeutic effectiveness and adverse reaction of hormonotherapy in treating nephrotic syndrome. METHODS: Patients allocated in two groups were medicated with initial dose of prednisone 1 mg/kg once a day at 8 am in the morning. After being medicated for 8 to 12 weeks, the dose of prednisone was decreased by 5.0 mg every 2 weeks till 0.5 mg/kg per day. Then the medication was changed to that two days' dosage orally take once a day with the daily dose reduced by 5.0 mg/kg every 2 to 3 weeks, and maintained at 0.4 mg/kg once every two days. At same time, necessary symptomatic treatment was given. To the treated group oral administration of liuwei dihuang pill 8 capsules was given additionally, 3 times per day until prednisone decreased to maintenance dose. RESULTS: Therapeutic effect in the treated group was significant better than that in the control group (P < 0.05). Urinary protein, plasma albumin, triglyceride (TG) and total cholesterol (TC) in both groups were obviously improved (P < 0.05 or P < 0.01). However, as compared with the control group, the improvement was better, and the recurrent rate was lower (P < 0.05) in the treated group. Scores of Yin-deficiency caused excessive Fire syndrome and incidence rate of adverse reaction in the treated group were lower than those in the control group (P < 0.05 or P < 0.01). CONCLUSION: liuwei dihuang pill can markedly improve the therapeutic effectiveness and counteract the adverse reaction of hormonotherapy in treating nephrotic syndrome, and reduce the recurrence of the disease.

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